A fatal case of progressive multifocal leukoencephalopathy has been reported in a multiple sclerosis patient taking Tecfidera (dimethyl fumarate). Although details of this case are still being disseminated, we believe the patient had not been previously treated with Tysabri or immunosuppressants, making this the first case of PML attributable to Tecfidera. Apparently the patient did have prolonged (>3 years) of lymphopenia (or a very low lymphocyte count), which is a known side effect of...

Thank you to all who attended the 17th Annual Tisch MS Research Patient Symposium.  In response to your requests, a review of the material presented will be posted on this website and appear in the next issue of our newsletter, Healing MS.

Dr. Duson Stefoski from Rush University in Chicago spoke at Grand Rounds this morning.  Dr. Stefoski is the Director of the Rush Multiple Sclerosis Center and has extensive experience in the diagnosis and management of Progressive Multifocal Leukoencephalopathy (PML). PML is the infection associated with prolonged Tysabri administration, for which there are no approved treatments.  Dr.

By: Dr. James W. Stark

10/9/14 - There has been much discussion in the news regarding some potentially serious viral infections going around close to home as well as around the world, including Enterovirus D68 and Ebola. In addition, we are entering influenza season, which can also be serious in certain patient populations. This is a good time to revisit some basic infection control principles that all of our patients should be doing to protect themselves and their loved ones.

At Grand Rounds this week, Senior Research Scientist,  Dr. Violaine Harris discussed the clinical need for CSF biomarker testing in MS and reviewed current research into the discovery and validation of CSF biomarkers. She highlighted the research from Tisch MS showing that a specific biomarker called Fetuin-A can be an accurate indicator of disease activity and therapeutic response. 

The IMSMP would like to wish all of those observing with their families, a happy Eid Al Adha!

The IMSMP would like to wish our Jewish patients, friends and supporters an easy fast on this Yom Kippur.


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